CO2 is ablative with more downtime and stronger results; pico fractional works beneath the surface with minimal downtime.
Medically reviewed by [DOCTOR NAME], board-certified dermatologist · Doje Clinic, Apgujeong, Seoul · Last reviewed November 2026
Side by side
| CO2 Fractional Laser | Pico Fractional Laser | |
|---|---|---|
| Category | Laser & Pigment | Laser & Pigment |
| Procedure time | 30–60 minutes | 20–30 minutes |
| Sessions | 1–3 sessions spaced months apart | Series of 3–5, monthly |
| Downtime | About 5–7 days of redness, crusting and peeling | Redness and pinpoint marks for 1–3 days |
| Results appear | Progressive over 3–6 months | Gradual over 2–3 months |
| Results last | Long-lasting | Long-lasting with a series |
| Comfort | Numbing cream; heat sensation | Numbing cream applied |
How CO2 Fractional Laser works
Each microscopic channel vaporizes tissue and heats surrounding collagen; healing skin rebuilds with tighter, smoother texture.
How Pico Fractional Laser works
Laser-induced optical breakdown creates micro-cavities in the dermis that trigger collagen renewal while leaving the surface mostly intact.
Choose CO2 Fractional Laser if you have
- deeper acne scars
- surgical scars
- significant texture and wrinkles
Choose Pico Fractional Laser if you have
- shallow acne scars
- enlarged pores
- fine lines
- texture improvement with less downtime than ablative lasers
Can you combine them?
Often, yes — your doctor will decide sequencing and timing based on your skin and travel dates.
Patient questions
Frequently asked questions
Which is better, CO2 Fractional Laser or Pico Fractional Laser?
CO2 is ablative with more downtime and stronger results; pico fractional works beneath the surface with minimal downtime.
Which has less downtime, CO2 Fractional Laser or Pico Fractional Laser?
CO2 Fractional Laser: about 5–7 days of redness, crusting and peeling. Pico Fractional Laser: redness and pinpoint marks for 1–3 days.
Which lasts longer?
CO2 Fractional Laser: long-lasting. Pico Fractional Laser: long-lasting with a series.
Not sure which one is right for you?
A Doje Clinic dermatologist will recommend the option that fits your skin, goals and travel dates.
Medical information on this page is general and educational. Results, downtime and suitability vary by individual. A consultation with a Doje Clinic physician is required before any treatment.