Rejuran uses polynucleotides through many micro-injections; Profhilo uses high-concentration HA through ten points. Rejuran focuses on repair; Profhilo on hydration and laxity.
Medically reviewed by [DOCTOR NAME], board-certified dermatologist · Doje Clinic, Apgujeong, Seoul · Last reviewed November 2026
Side by side
| Rejuran Healer | Profhilo | |
|---|---|---|
| Category | Skin Boosters | Skin Boosters |
| Procedure time | 20–40 minutes | 15–20 minutes |
| Sessions | Typically 3 sessions 2–4 weeks apart | 2 sessions 4 weeks apart |
| Downtime | Small bumps for 1–2 days; possible pinpoint bruising | Small bumps for up to 24 hours |
| Results appear | Gradual over 2–3 sessions | Over 4–8 weeks |
| Results last | Around 6–12 months after a full course | About 6 months |
| Comfort | Many injection points; numbing cream applied for comfort | Few injection points; mild discomfort |
How Rejuran Healer works
Polynucleotides support the skin's healing environment and fibroblast activity, helping thickness, elasticity and fine texture improve gradually.
How Profhilo works
Stabilized HA is injected at five points per side and disperses evenly, supporting collagen and elastin production.
Choose Rejuran Healer if you have
- thin or damaged skin
- fine lines
- enlarged pores
- post-laser recovery
- sensitive skin
Choose Profhilo if you have
- early laxity
- crepey skin on face and neck
- dehydrated mature skin
Can you combine them?
Often, yes — your doctor will decide sequencing and timing based on your skin and travel dates.
Patient questions
Frequently asked questions
Which is better, Rejuran Healer or Profhilo?
Rejuran uses polynucleotides through many micro-injections; Profhilo uses high-concentration HA through ten points. Rejuran focuses on repair; Profhilo on hydration and laxity.
Which has less downtime, Rejuran Healer or Profhilo?
Rejuran Healer: small bumps for 1–2 days; possible pinpoint bruising. Profhilo: small bumps for up to 24 hours.
Which lasts longer?
Rejuran Healer: around 6–12 months after a full course. Profhilo: about 6 months.
Not sure which one is right for you?
A Doje Clinic dermatologist will recommend the option that fits your skin, goals and travel dates.
Medical information on this page is general and educational. Results, downtime and suitability vary by individual. A consultation with a Doje Clinic physician is required before any treatment.